Anabolic Steroids, World Anti-Doping Agency

DOCUMENT: Application | Ref: 203-821-387Download
Category: Forensics Toxicology, Separation Science Mass Spectrometry, TOF Mass Spectrometry

Enhanced Detection and Separation of Anabolic Steroids for Anti-Doping Control Screening by Comprehensive Two-Dimensional Gas Chromatography Time-of-Flight Mass Spectrometry (GCxGC-TOFMS)

This application demonstrates that steroid screening by GCxGC-TOFMS is improved significantly compared to one dimensional chromatography using single quadrupole GCMS. Excellent calibration linearity for quantitation was achieved for all analytes at greater than 99.9%. Limits of detection at part per trillion levels were calculated from acquired data for all five steroids. This research demonstrates the ability of GCxGC-TOFMS to provide enhanced analyte detectability, deconvolution of trace le