Urine, Liver, Drugs, Deconvolution, Metabolomics

DOCUMENT: Application | Ref: 203-821-302Download
Category: Forensics Toxicology, Separation Science Mass Spectrometry, TOF Mass Spectrometry

GC-TOFMS Analysis of Urine Extract Samples Used for a Liver Drug-Induced Injury Study

High-speed acquisition rates allowed the analysis of each urine sample in about 15 minutes. The fast analysis came with no loss in the ability to fully characterize the samples for the study. The spectral continuity across the chromatographic peak profile specific to TOFMS instruments, combined with unique ChromaTOF Peak Find and Deconvolution algorithms, enabled detection and mass spectral characterization of more than 650 peaks in each of the samples studied. With more metabolites detected for any given sample, the potential of finding discriminatory peaks for each metabolome increase